Khefrem is a coastal region in southwestern Hammerfell, meeting the waters of the Eltheric Ocean and Hubalajad's Bay. The city of Gilane and ruins of the Rourken capital are part of the region. It contains the peninsula of Hew's Bane, which was originally known as Khefrem's Boot.
In 2E 582, two Daggerfall Covenant officers, Lakhazga gro-Rimat and Morothmash gro-Uzug, defected and fled from Glenumbra to the wilds of Khefrem, where they contacted the Aldmeri Dominion through a Baandari peddler. The Covenant learned about this, and pursued them across the Abecean Sea to Auridon, where the two were ultimately saved from capture by the Vestige. In the same year, Madam Firilanya, a famous clothier, made landfall in Khefrem during her trip from Anvil to the Alik'r Desert.
The region is also home to the Khefrem Academy of Yokudan Heritage.